Perturbations in Eosinophil Homeostasis following Treatment of Lymphatic Filariasis
Identifieur interne : 00A207 ( Main/Exploration ); précédent : 00A206; suivant : 00A208Perturbations in Eosinophil Homeostasis following Treatment of Lymphatic Filariasis
Auteurs : Ramya Gopinath ; L. E. Hanna ; V. Kumaraswami ; V. Perumal ; V. Kavitha ; V. Vijayasekaran ; Thomas B. NutmanSource :
- Infection and Immunity [ 0019-9567 ] ; 2000.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Animaux, Chimiokine CCL5 (sang), Chimiokines (sang), Cytokines (sang), Cytométrie en flux, Diéthylcarbamazine (usage thérapeutique), Dégranulation cellulaire (), Facteurs temps, Filaricides (usage thérapeutique), Filariose lymphatique (sang), Filariose lymphatique (traitement médicamenteux), Granulocytes éosinophiles (), Granulocytes éosinophiles (physiologie), Homéostasie, Humains, Interleukine-5 (sang), Mâle, Wuchereria bancrofti, Études cas-témoins.
- MESH :
- physiologie : Granulocytes éosinophiles.
- sang : Chimiokine CCL5, Chimiokines, Cytokines, Filariose lymphatique, Interleukine-5.
- traitement médicamenteux : Filariose lymphatique.
- usage thérapeutique : Diéthylcarbamazine, Filaricides.
- Adulte, Adulte d'âge moyen, Animaux, Cytométrie en flux, Dégranulation cellulaire, Facteurs temps, Granulocytes éosinophiles, Homéostasie, Humains, Mâle, Wuchereria bancrofti, Études cas-témoins.
English descriptors
- KwdEn :
- Adult, Animals, Case-Control Studies, Cell Degranulation (drug effects), Chemokine CCL5 (blood), Chemokines (blood), Cytokines (blood), Diethylcarbamazine (therapeutic use), Elephantiasis, Filarial (blood), Elephantiasis, Filarial (drug therapy), Eosinophils (drug effects), Eosinophils (physiology), Filaricides (therapeutic use), Flow Cytometry, Homeostasis, Humans, Interleukin-5 (blood), Male, Middle Aged, Time Factors, Wuchereria bancrofti.
- MESH :
- chemical , blood : Chemokine CCL5, Chemokines, Cytokines, Interleukin-5.
- blood : Elephantiasis, Filarial.
- drug effects : Cell Degranulation, Eosinophils.
- drug therapy : Elephantiasis, Filarial.
- physiology : Eosinophils.
- chemical , therapeutic use : Diethylcarbamazine, Filaricides.
- Adult, Animals, Case-Control Studies, Flow Cytometry, Homeostasis, Humans, Male, Middle Aged, Time Factors, Wuchereria bancrofti.
Abstract
Treatment of patients with patent
Url:
PubMed: 10603373
PubMed Central: 97106
Affiliations:
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Le document en format XML
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Animals</term>
<term>Case-Control Studies</term>
<term>Cell Degranulation (drug effects)</term>
<term>Chemokine CCL5 (blood)</term>
<term>Chemokines (blood)</term>
<term>Cytokines (blood)</term>
<term>Diethylcarbamazine (therapeutic use)</term>
<term>Elephantiasis, Filarial (blood)</term>
<term>Elephantiasis, Filarial (drug therapy)</term>
<term>Eosinophils (drug effects)</term>
<term>Eosinophils (physiology)</term>
<term>Filaricides (therapeutic use)</term>
<term>Flow Cytometry</term>
<term>Homeostasis</term>
<term>Humans</term>
<term>Interleukin-5 (blood)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Time Factors</term>
<term>Wuchereria bancrofti</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Animaux</term>
<term>Chimiokine CCL5 (sang)</term>
<term>Chimiokines (sang)</term>
<term>Cytokines (sang)</term>
<term>Cytométrie en flux</term>
<term>Diéthylcarbamazine (usage thérapeutique)</term>
<term>Dégranulation cellulaire ()</term>
<term>Facteurs temps</term>
<term>Filaricides (usage thérapeutique)</term>
<term>Filariose lymphatique (sang)</term>
<term>Filariose lymphatique (traitement médicamenteux)</term>
<term>Granulocytes éosinophiles ()</term>
<term>Granulocytes éosinophiles (physiologie)</term>
<term>Homéostasie</term>
<term>Humains</term>
<term>Interleukine-5 (sang)</term>
<term>Mâle</term>
<term>Wuchereria bancrofti</term>
<term>Études cas-témoins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Chemokine CCL5</term>
<term>Chemokines</term>
<term>Cytokines</term>
<term>Interleukin-5</term>
</keywords>
<keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Elephantiasis, Filarial</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cell Degranulation</term>
<term>Eosinophils</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Elephantiasis, Filarial</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Granulocytes éosinophiles</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Eosinophils</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Chimiokine CCL5</term>
<term>Chimiokines</term>
<term>Cytokines</term>
<term>Filariose lymphatique</term>
<term>Interleukine-5</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Diethylcarbamazine</term>
<term>Filaricides</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Filariose lymphatique</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Diéthylcarbamazine</term>
<term>Filaricides</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Animals</term>
<term>Case-Control Studies</term>
<term>Flow Cytometry</term>
<term>Homeostasis</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Time Factors</term>
<term>Wuchereria bancrofti</term>
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<term>Adulte d'âge moyen</term>
<term>Animaux</term>
<term>Cytométrie en flux</term>
<term>Dégranulation cellulaire</term>
<term>Facteurs temps</term>
<term>Granulocytes éosinophiles</term>
<term>Homéostasie</term>
<term>Humains</term>
<term>Mâle</term>
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<front><div type="abstract" xml:lang="en"><p>Treatment of patients with patent <italic>Wuchereria bancrofti</italic>
infection results in an acute clinical reaction and peripheral eosinophilia. To investigate the dynamics of the eosinophil response, changes in eosinophil activation and degranulation and plasma levels of eosinophil-active chemokines and cytokines were studied in 15 microfilaremic individuals in south India by sequential blood sampling before and after administration of 300 mg of diethylcarbamazine (DEC). Clinical symptoms occurred within 24 h. Plasma interleukin-5 (IL-5) and RANTES levels peaked 1 to 2 days posttreatment, preceding a peak peripheral eosinophil count at day 4. Major basic protein secretion from eosinophils paralleled IL-5 secretion, while levels of eosinophil-derived neurotoxin peaked at day 13 after treatment. Expression of the activation markers HLA-DR and CD25 on eosinophils rose markedly immediately after treatment, while expression of VLA-4 and α4β7 showed an early peak within 24 h and a second peak at day 13. Thus, the posttreatment reactions seen in filarial infections can be divided into an early phase with killing of microfilariae, clinical symptomatology, increases in plasma IL-5 and RANTES levels, and eosinophil activation and degranulation and a later phase with expression of surface integrins on eosinophils, recruitment of eosinophils from the bone marrow to tissues, and clearance of parasite antigen.</p>
</div>
</front>
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<affiliations><list></list>
<tree><noCountry><name sortKey="Gopinath, Ramya" sort="Gopinath, Ramya" uniqKey="Gopinath R" first="Ramya" last="Gopinath">Ramya Gopinath</name>
<name sortKey="Hanna, L E" sort="Hanna, L E" uniqKey="Hanna L" first="L. E." last="Hanna">L. E. Hanna</name>
<name sortKey="Kavitha, V" sort="Kavitha, V" uniqKey="Kavitha V" first="V." last="Kavitha">V. Kavitha</name>
<name sortKey="Kumaraswami, V" sort="Kumaraswami, V" uniqKey="Kumaraswami V" first="V." last="Kumaraswami">V. Kumaraswami</name>
<name sortKey="Nutman, Thomas B" sort="Nutman, Thomas B" uniqKey="Nutman T" first="Thomas B." last="Nutman">Thomas B. Nutman</name>
<name sortKey="Perumal, V" sort="Perumal, V" uniqKey="Perumal V" first="V." last="Perumal">V. Perumal</name>
<name sortKey="Vijayasekaran, V" sort="Vijayasekaran, V" uniqKey="Vijayasekaran V" first="V." last="Vijayasekaran">V. Vijayasekaran</name>
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